Zwitterionic 3'-O-acyl derivatives of thymidine 5'-phosphate as potential sources of intracellular thymidine 5'-phosphate in cells in culture

…, JJ Freed, F Kappler, A Hampton

Index: Chawla, Ram R.; Freed, Jerome J.; Kappler, Francis; Hampton, Alexander Journal of Medicinal Chemistry, 1986 ,  vol. 29,  # 5  p. 797 - 802

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Citation Number: 10

Abstract

A convenient route is described for attachment of acyl groups (1) CO (CHz) nN (Et) 2 (CHJ, NH (Et) 2 (h= 3, m= 2; n= 4, m= 2-4),(2) CO (CHz) nN (Et) z (CHz), NEt3 (n= 4, m= 2-4), or (3) CO (CHz) 4N (CH2CHz) 3N (CH2) nCH3 (n= 1 or 9) to 0-3'of thymidine 5'-phosphate (TMP). The compounds are prototypes of 5'-nucleotide derivatives in which the two anionic charges could become partially masked in intramolecular anionic-cationic interactions and which ...