Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype

…, RJ Himmelsbach, A Chucholowski…

Index: Blankley, C. John; Hodges, John C.; Klutchko, Sylvester R.; Himmelsbach, Richard J.; Chucholowski, Alexander; et al. Journal of Medicinal Chemistry, 1991 ,  vol. 34,  # 11  p. 3248 - 3260

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Citation Number: 154

Abstract

Structureactivity relationships are reported for a novel class of 4, 5, 6, 7-tetrahydro-lH- imidaz0 [4, 5-c] pyridine-6-carboxylic acid derivatives that displace'Wabeled angiotensin I1 from a specific subset of angiotensin I1 (Ang 11) binding sites in rat adrenal preparations. This binding site is not the Ang 11 receptor mediating vascular contraction or aldosterone release, but, rather, is one whose function has not yet been fully elucidated. It has been ...