Structure-activity relationships of 1-(2-deoxy-2-fluoro-β-l-arabino-furanosyl) pyrimidine nucleosides as anti-hepatitis B virus agents

…, YL Zhu, JS Lin, K Shanmuganathan, J Du…

Index: Ma, Tianwei; Pai, S. Balakrishna; Zhu, Yong Lian; Lin, Ju Sheng; Shanmuganathan, Kirupa; Du, Jinfa; Wang, Chunguang; Kim, Hongbum; Newton, M. Gary; Cheng, Yung Chi; Chu, Chung K. Journal of Medicinal Chemistry, 1996 ,  vol. 39,  # 14  p. 2835 - 2843

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Citation Number: 157

Abstract

Since 2'-fluoro-5-methyl-β-l-arabinofuranosyluracil (l-FMAU) has been shown to be a potent anti-HBV agent in vitro, it was of interest to study the structure-activity relationships of related nucleosides. Thus, a series of 1-(2-deoxy-2-fluoro-β-l-arabinofuranosyl) pyrimidine nucleosides have been synthesized and evaluated for antiviral activity against HBV in 2.2. 15 cells. For this study, l-ribose was initially used as the starting material. Due to the ...