An efficient and safe procedure for the large-scale Pd-catalyzed hydrazonation of aromatic chlorides using buchwald technology

CC Mauger, GA Mignani

Index: Mauger, Christelle C.; Mignani, Gerard A. Organic Process Research and Development, 2004 , vol. 8, # 6 p. 1065 - 1071

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Citation Number: 32

Abstract

A convenient, optimized and safe synthesis of N-arylhydrazines, useful as intermediates for active ingredients in agricultural and pharmaceutical applications, is reported. Starting from aryl halides (chlorides and bromides), a palladium-catalyzed carbon-nitrogen coupling reaction followed by an acidic treatment afforded the target molecules in good to excellent yields using low catalyst loadings. This technology has then been successfully applied on ...