Chemical Communications

Syntheis and structure of cis-peptidyl prolinamide mimetics based upon 1, 2, 5-triazepine-3, 6-diones

MM Lenman, SL Ingham, D Gani

Index: Lenman, Morag M.; Ingham, Scott L.; Gani, David Journal of the Chemical Society, Chemical Communications, 1996 ,  # 1  p. 85 - 88

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Citation Number: 21

Abstract

The synthesis of novel constrained cis-peptidyl prolinamide mimetics for the dipeptide amides glycyl (2S)-prolinamide,(2S)-alanyl (2S)-prolinamide and (2R)-alanyl (2S) prolinamide and some analogues, based upon fused 1, 2, 5-triazepine-3, 6-diones, is described; these are suitable for elaboration into larger peptides at both the carboxy and amino termini, X-ray crystal structures for some of the compounds and intermediates are ...