Synthesis of diastereomerically pure nucleotide phosphoramidates

BS Ross, P Ganapati Reddy, HR Zhang…

Index: Ross, Bruce S.; Ganapati Reddy; Zhang, Hai-Ren; Rachakonda, Suguna; Sofia, Michael J. Journal of Organic Chemistry, 2011 ,  vol. 76,  # 20  p. 8311 - 8319

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Citation Number: 37

Abstract

Prodrugs of therapeutic nucleoside monophosphates masked as phosphoramidate derivatives have become an increasingly important class of antiviral drugs in pharmaceutical research for delivering nucleotides in vitro and in vivo. Conventionally, phosphoramidate derivatives are prepared as a mixture of two diastereomers. We report a class of stable phosphoramidating reagents containing an amino acid ester and two phenolic groups, ...