Nucleotide chemistry. 16. Amidine protecting groups for oligonucleotide synthesis
…, R Kierzek, SL Beaucage, MH Caruthers
Index: McBride, Lincoln J.; Kierzek, Ryszard; Beaucage, Serge L.; Caruthers, Marvin H. Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2040 - 2048
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Citation Number: 207
Abstract
Abstract: Amidines have been investigated for protection of deoxyadenosine, deoxycytidine, 5-methyldeoxycytidine, cytidine, and deoxyguanosine. These amidine-protected nucleosides and their 5'-bis (p-anisylphenyI) methyl derivatives were prepared in high yield (79-100%) by simple one-flask procedures, converted to their respective phosphoramidites [3'-O-((diiso-propylamino) methoxyphosphino)] with bis (diisopropylamino) ...
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