Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase

…, F Zulfiqar, T Miyamoto, M Nakanishi, Y Kitade

Index: Ando, Takayuki; Iwata, Masafumi; Zulfiqar, Fazila; Miyamoto, Tatsuya; Nakanishi, Masayuki; Kitade, Yukio Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 3809 - 3815

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Citation Number: 15

Abstract

2-Modified aristeromycin derivatives and their related analogs were synthesized to investigate their inhibitory activity against human and Plasmodium falciparum S-adenosyl-l- homocysteine hydrolase (PfSAHH). 2-Fluoroaristeromycin showed a strong inhibitory activity against PfSAHH selectively and complete resistance to adenosine deaminase.