Synthesis of a. BETA.-Tetrapeptide Analog as a Mother Compound for the Development of Matrix Metalloproteinase-2-Imaging Agents

…, K Soejima, J Sasaki, F Yamamoto, M Maeda

Index: Mukai, Takahiro; Suganuma, Noriko; Soejima, Kenta; Sasaki, Junichi; Yamamoto, Fumihiko; Maeda, Minoru Chemical and Pharmaceutical Bulletin, 2008 ,  vol. 56,  # 3  p. 260 - 265

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Citation Number: 15

Abstract

Matrix metalloproteinase-2 (MMP-2) is an attractive target for the diagnosis of cancer and atherosclerosis in nuclear imaging. A cyclic decapeptide, cCTTHWGFTLC (cCTT), has been used as the mother compound for the development of MMP-2-imaging agents with high potency and selectivity. Most of radiolabeled derivatives of cCTT currently developed for in vivo studies of MMP-2, however, suffer from low accumulation in the target tissues, such ...