Tetrahedron letters

A convenient and efficient method for the synthesis of mono-and N, N-disubstituted thioureas

M Kodomari, M Suzuki, K Tanigawa, T Aoyama

Index: Kodomari, Mitsuo; Suzuki, Masato; Tanigawa, Keiko; Aoyama, Tadashi Tetrahedron Letters, 2005 ,  vol. 46,  # 35  p. 5841 - 5843

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Citation Number: 49

Abstract

A convenient method for the synthesis of mono-and N, N-disubstituted thioureas by the debenzoylation of N-substituted-and N, N-disubstituted-N′-benzoylthioureas with hydrazine hydrate under solvent-free conditions has been developed. N-Substituted-N′- benzoylthioureas and hydrazine hydrate were mixed, and stirred at room temperature without a solvent to give the corresponding N-substituted thioureas in high yields.