Stereospecific synthesis and biological evaluations of β-L-pentofuranonucleoside derivatives of 5-fluorouracil and 5-fluorocytosine

…, A Faraj, AM Aubertin, E De Clercq, J Balzarini…

Index: Griffon, Jean-Francois; Mathe, Christophe; Faraj, Abdesslem; Aubertin, Anne-Marie; De Clercq, Erik; Balzarini, Jan; Sommadossi, Jean-Pierre; Gosselin, Gilles European Journal of Medicinal Chemistry, 2001 , vol. 36, # 5 p. 447 - 460

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Citation Number: 16

Abstract

In the search for new chemotherapeutic agents, we have focused our work on the synthesis and the study of several unnatural β-l-nucleoside analogues. In this paper, we report on the synthesis of β-l-pentofuranonucleosides (and their 2′-deoxy derivatives) of 5-fluorouracil and their inhibitory effects on the proliferation of several murine and human tumor cells. The corresponding 5-fluorocytosine derivatives were also synthesized and their anti-HIV and ...