Two new orthogonal amine-protecting groups that can be cleaved under mild or neutral conditions

…, R Madsen, C Roberts, B Fraser-Reid

Index: Debenham, John S.; Madsen, Robert; Roberts, Carmichael; Fraser-Reid, Bert Journal of the American Chemical Society, 1995 , vol. 117, # 11 p. 3302 - 3303

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Citation Number: 140

Abstract

Amines are widespread among biologically important natural products that are the foci of extensive synthetic effort? Because of their high reactivity, amines must usually be protected during synthetic operation^,^ the protecting group frequently serving the additional purpose of negating the amine's basicity, a task which can be efficiently accomplished by acylation. However, deprotection of the resulting amides or carbamates requires conditions that may ...