An Efficient Procedure for the Synthesis of Benzimidazole Derivatives Using Yb (OTf) 3 as Catalyst Under Solvent??Free Conditions
L Wang, J Sheng, H Tian, C Qian
Index: Wang, Limin; Sheng, Jia; Tian, He; Qian, Changtao Synthetic Communications, 2004 , vol. 34, # 23 p. 4265 - 4272
Full Text: HTML
Citation Number: 42
Abstract
Abstract o??Diaminobenzene derivatives react smoothly with ortho??esters in the presence of 0.5 mol% of Yb (OTf) 3 under solvent??free conditions to afford the corresponding benzimidazole derivatives in good to excellent yields. In addition, Yb (OTf) 3 can be easily recovered almost quantitatively from the aqueous layer after the reaction was completed, and it could be reused with no loss of activity.
Related Articles:
[VanVliet, David S.; Gillespie, Paul; Scicinski, Jan J. Tetrahedron Letters, 2005 , vol. 46, # 39 p. 6741 - 6743]
Synthesis of benzimidazole derivatives using heterogeneous ZnO nanoparticles
[Alinezhad, Heshmatollah; Salehian, Fatemeh; Biparva, Pourya Synthetic Communications, 2012 , vol. 42, # 1 p. 102 - 108]
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists
[Davies, David J.; Crowe, Matthew; Lucas, Nolwenn; Quinn, Joanna; Miller, David D.; Pritchard, Sara; Grose, David; Bettini, Ezio; Calcinaghi, Novella; Virginio, Caterina; Abberley, Lee; Goldsmith, Paul; Michel, Anton D.; Chessell, Iain P.; Kew, James N.C.; Miller, Neil D.; Gunthorpe, Martin J. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2620 - 2623]
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists
[Davies, David J.; Crowe, Matthew; Lucas, Nolwenn; Quinn, Joanna; Miller, David D.; Pritchard, Sara; Grose, David; Bettini, Ezio; Calcinaghi, Novella; Virginio, Caterina; Abberley, Lee; Goldsmith, Paul; Michel, Anton D.; Chessell, Iain P.; Kew, James N.C.; Miller, Neil D.; Gunthorpe, Martin J. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2620 - 2623]
[Selvam, Kaliyamoorthy; Annadhasan, Mari; Velmurugan, Rengasamy; Swaminathan, Meenakshisundaram Bulletin of the Chemical Society of Japan, 2010 , vol. 83, # 7 p. 831 - 837]