Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties

…, A Menzek, E Sahin, M Tanc, CT Supuran

Index: Akbaba, Yusuf; Akincioglu, Akin; Goecer, Huelya; Goeksu, Sueleyman; Guelcin, Ilhami; Supuran, Claudiu T. Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 1 p. 35 - 42

Full Text: HTML

Citation Number: 42

Abstract

Cyclopropylcarboxylic acids and esters and cyclopropylmethanols incorporating bromophenol moieties were investigated as inhibitors of the carbonic anhydrase enzyme (CA; EC 4.2. 1.1). The cis-and trans-esters 5 and 6 were obtained from the reaction of 4-allyl-