Hydroxyphthalocyanines as potential photodynamic agents for cancer therapy

M Hu, N Brasseur, SZ Yildiz, JE van Lier…

Index: Hu, Mougang; Brasseur, Nicole; Zeki Yildiz; Van Lier, Johan E.; Leznoff, Clifford C. Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1789 - 1802

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Citation Number: 111

Abstract

A series of benzyl-substituted phthalonitriles, substituted at the 3-, 4-, and 4, 5-positions, underwent varied condensations with phthalonitrile to give a series of protected (monohydroxy-and polyhydroxyphthalocyaninato) zinc (II) derivatives which were readily cleaved to give several hydroxyphthalocyanines (ZnPc)(phthalocyanine phenol analogues). Their efficacy as sensitizers for the photodynamic therapy (PDT) of cancer was evaluated ...