Application of Ynamides in the Synthesis of 2-Amidoindoles
K Dooleweerdt, T Ruhland, T Skrydstrup
Index: Dooleweerdt, Karin; Ruhland, Thomas; Skrydstrup, Troels Organic Letters, 2009 , vol. 11, # 1 p. 221 - 224
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Citation Number: 54
Abstract
A Pd-catalyzed, one-pot, two-step synthesis of 2-amidoindoles from ynamides and o- iodoanilines is reported. A key highlight of this sequence is that after the Sonogashira reaction, intramolecular cyclization to the indole occurs spontaneously without activation of the alkyne.
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