Synthetic utility of ammonium salts in a Cu-catalyzed three-component reaction as a facile coupling partner

…, SY Lee, J Lee, Y Do, S Chang

Index: Kim, Jinho; Lee, S. Yunmi; Lee, Junseung; Do, Youngkyu; Chang, Sukbok Journal of Organic Chemistry, 2008 , vol. 73, # 23 p. 9454 - 9457

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Citation Number: 77

Abstract

Ammonium salts were found to be a convenient and inexpensive reagent in the Cu- catalyzed three-component reaction with terminal alkynes and sulfonyl or phosphoryl azides leading to N-unprotected amidines. Thus obtained amidines bearing 2- bromobenzenesulfonyl moiety were efficiently cyclized by the Cu-catalyzed intramolecular N- arylation to give an important pharmacophore skeleton of 2 H-1, 2, 4-benzothiadiazine 1, ...