Nitric oxide-donating non-steroidal anti-inflammatory drugs: the case of nitroderivatives of aspirin

V Chiroli, F Benedini, E Ongini, P Del Soldato

Index: Chiroli, Valerio; Benedini, Francesca; Ongini, Ennio; Del Soldato, Piero European Journal of Medicinal Chemistry, 2003 , vol. 38, # 4 p. 441 - 446

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Citation Number: 53

Abstract

Nitric oxide (NO) acts as a key signalling mechanism in a number of cells and tissues in the mammalian organism. Modulation of the biosynthesis of NO has emerged to be relevant to the treatment of a variety of human diseases. In the attempt to reduce the serious side effects of non-steroidal anti-inflammatory drugs (NSAIDs), especially in the gastrointestinal tract, a NO-releasing moiety has been linked to conventional NSAIDs. A prototypical example is ...