Tetrahedron Letters

Direct synthesis of δ-lactones from 2-(3-lithiopropyl)-1, 3-dioxolane and carbonyl compounds

DJ Ramón, M Yus

Index: Ramon, Diego J.; Yus, Miguel Tetrahedron Letters, 1990 , vol. 31, # 26 p. 3767 - 3770

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Citation Number: 14

Abstract

Abstract The reaction of 2-(3-lithiopropyl)-1, 3-dioxolane (2), prepared in situ by lithiation of the chloroacetal 1 with lithium naphthalenide at− 78 C, with aldehydes and ketones followed by hydrolysis with hydrochloric acid and final oxidation with PCC or Jones reagent yields the

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