Synthesis of Cinnamide Dimers as Potential Antibacterial and Antifungal Agents

A Kamal, G Ramakrishna, P Raju…

Index: Kamal, Ahmed; Ramakrishna; Raju; Subba Rao; Joseph, Joveeta; Siddhardha; Murty Letters in Drug Design and Discovery, 2011 , vol. 8, # 10 p. 957 - 965

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Abstract

A series of new cinnamide dimers was synthesized (5a-6a) and evaluated for their antimicrobial and antifungal activity. All the compounds investigated have shown significant antimicrobial activity against gram-positive and gram-negative bacterial strains, as well as few fungal strains. The compounds having withdrawing group exhibited significant biological activity than their precursors. Moreover all the compounds containing electron ...