Die Synthese von 6, 7??Dihydro??2H??pyrimido [6, 1??a] isochinolin??4 (3H)??onen und analogen Verbindungen und deren Wirkung als Blutpättchenaggregationshemmer

F Kienzle, Y Bounameaux, RE Minder…

Index: Kienzle; Bounameaux; Minder; Muggli Helvetica Chimica Acta, 1986 , vol. 69, # 7 p. 1671 - 1680

Full Text: HTML

Citation Number: 7

Abstract

The synthesis of 6, 7-dihydro-2H-pyrimido [6, Iu] isoquinolin-4 (3H)-ones and of analogous compounds is described. These compounds are powerful phosphodiesterase inhibitors and, therefore, inhibit blood-platelet aggregation independent of the agonist. They exhibit, too, cardiac activities. However, there is evidence for selective action. A structure-activity relationship for platelet-aggregation inhibitors is discussed.