Journal of chemical crystallography

Sequential reaction of p-toluidine with 2, 3-dichloromaleic anhydride: Synthesis and molecular structure of 2-chloro-3-p-toluidino-Np-tolylmaleimide

WH Watson, G Wu, MG Richmond

Index: Watson, William H.; Wu, Guanmin; Richmond, Michael G. Journal of Chemical Crystallography, 2003 , vol. 33, # 12 p. 983 - 988

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Citation Number: 6

Abstract

Abstract The reaction of equimolar amounts of p-toluidine with 2, 3-dichloromaleic anhydride in refluxing toluene affords 2, 3-dichloro-Np-tolylmaleimide (1) and 2-chloro-3-p-toluidino- Np-tolylmaleimide (2), as the major and minor products, respectively. While increasing the amount of p-toluidine relative to 2, 3-dichloromaleic anhydride yields the latter compound as the major product, the replacement of the chloro group in 2-chloro-3-p-toluidino-Np- ...