Israel Journal of Chemistry

Structure–Activity Relationship Studies in Single??Site Esterase Peptide Dendrimers

S Javor, JL Reymond

Index: Javor, Sacha; Reymond, Jean-Louis Israel Journal of Chemistry, 2009 , vol. 49, # 1 p. 129 - 136

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Citation Number: 10

Abstract

Abstract We recently reported on peptide dendrimers with a single catalytic site at the dendrimer core catalyzing the hydrolysis of acetoxy-and butyryloxy-pyrene trisulfonate 1a/b in aqueous buffer with Michaelis–Menten kinetics. Substrate binding is mediated by a pair of protonated arginine or histidine residues in the first generation branch, and esterolysis is performed by the imidazole side-chain of a histidine residue in the core acting as a ...