Synthesis and biological screening of 5-(alkyl (1H-indol-3-yl))-2-(substituted)-1, 3, 4-oxadiazoles as antiproliferative and anti-inflammatory agents

S Rapolu, M Alla, VR Bommena, R Murthy…

Index: Rapolu, Sreevani; Alla, Manjula; Bommena, Vittal Rao; Murthy, Ramalinga; Jain, Nishant; Bommareddy, Venkata Ramya; Bommineni, Madhava Reddy European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 91 - 100

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Citation Number: 21

Abstract

Abstract A series of 5-(alkyl (1H-indol-3-yl))-2-(substituted)-1, 3, 4-oxadiazoles were efficiently synthesized by oxidative cyclisation of N′-benzylidene-(1H-indol-3-yl) alkane hydrazides using di (acetoxy) iodobenzene. N′-Benzylidene-(1H-indol-3-yl) alkane hydrazides themselves were derived from simple indole-3-carboxylic acids. The 5-(alkyl (1H- indol-3-yl))-2-(substituted)-1, 3, 4-oxadiazoles were evaluated for their anti-inflammatory ...