Expedient one-pot organometallics-free synthesis of tris (2-pyridyl) phosphine from 2-bromopyridine and elemental phosphorus

…, AV Artem'ev, SF Malysheva, NK Gusarova…

Index: Trofimov, Boris A.; Artem'Ev, Alexander V.; Malysheva, Svetlana F.; Gusarova, Nina K.; Belogorlova, Nataliya A.; Korocheva, Anastasiya O.; Gatilov, Yuriy V.; Mamatyuk, Victor I. Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2424 - 2427

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Citation Number: 18

Abstract

2-Bromopyridine reacts with elemental phosphorus (red or white) in a superbasic KOH/DMSO (H2O) suspension at 100° C (for red phosphorus) and 75° C (for white phosphorus) over 3h to afford tris (2-pyridyl) phosphine in a 62% yield (from red phosphorus) and a 50% yield (from white phosphorus). Under microwave assistance, the reaction with red phosphorus takes just 20min to produce tris (2-pyridyl) phosphine in 53 ...