Synthesis and cytotoxicity of some d-mannose click conjugates with aminobenzoic acid derivatives

L Hradilová, M Poláková, B Dvořáková, M Hajdúch…

Index: OJI PAPER CO., LTD. Patent: EP1264707 A2, 2002 ;

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Citation Number: 12

Abstract

... Reagents and conditions: (a) alcohol, NaH, toluene, reflux, 2 h, 4a(91%), 4b(89%), 4c(56%), 4d(48%), 4f(82%); (b) 5a–c,6a–c: alcohol and thionylchloride, 30–65 °C, 4–10 h; 5d,6d: K 2 CO 3 , octyl chloride, DMF, 70–80 °C, 2 h; 5f,6f: K 2 CO 3 , propargyl bromide, DMF, rt, 1 h, 5a ...