The reactivity of 1-chloro-3, 3-dimethylbicyclo [2.2. 2] octan-2-one in the radical mechanism of nucleophilic substitution

AN Santiago, K Takeuchi, Y Ohga…

Index: Santiago, Ana N.; Takeuchi, Ken'ichi; Ohga, Yasushi; Nishida, Mitsuo; Rossi, Roberto A. Journal of Organic Chemistry, 1991 , vol. 56, # 4 p. 1581 - 1584

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Citation Number: 24

Abstract

The radical mechanism of nucleophilic substitution, or SRN1, is a well-known process by which a substitution is produced on adequately substituted substrate^.^ This nucleophilic substitution mechanism is a chain process which involves radicals and radical anions as intermediates. The main steps of this mechanism are sketched in Scheme I. Scheme I (RX)'- - R' + X- (1) R' + Nu- - (RNu)'- (2) (RNu)'- + RX - RNu' + (RX)'- (3) ... This mechanism of nucleophilic ...