Antiviral Atropisomers: Conformational Energy Surfaces by NMR for Host-Directed Myxovirus Blockers

…, G Wells, S Wu, A Sun, JP Snyder

Index: Sun, Aiming; Ndungu, J. Maina; Krumm, Stefanie A.; Yoon, Jeong-Joong; Thepchatri, Pahk; Natchus, Michael; Plemper, Richard K.; Snyder, James P. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 11 p. 798 - 803

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Citation Number: 3

Abstract

Biologically active organic molecules characterized by a high single bond torsional barrier generate isolable isomers (atropisomers) and offer a unique stereochemical component to the design of selective therapeutic agents. The present work presents a nanomolar active