A mild and efficient chemoselective protection of amines as N-benzyloxycarbonyl derivatives in the presence of La (NO 3) 3· 6H 2 O under solvent-free conditions

KC Mahesh, M Narasimhulu, TS Reddy, N Suryakiran…

Index: Chinni Mahesh; Narasimhulu; Srikanth Reddy; Suryakiran; Venkateswarlu Tetrahedron Letters, 2007 , vol. 48, # 1 p. 55 - 59

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Citation Number: 19

Abstract

A facile and versatile method for the chemoselective N-benzyloxycarbonylation of amines has been developed by treatment with benzyloxycarbonyl chloride (Cbz–Cl) in the presence of lanthanum (III) nitrate hexahydrate under solvent-free conditions. The method is general for the preparation of N-Cbz derivatives of aliphatic (acyclic and cyclic) and aromatic amines.

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