Identification of pyrimidine derivatives as hSMG-1 inhibitors

A Gopalsamy, EM Bennett, M Shi, WG Zhang…

Index: Gopalsamy, Ariamala; Shi, Mengxiao; Bennett, Eric M.; Bard, Joel; Zhang, Wei-Guo; Yu, Ker Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6636 - 6641,6

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Citation Number: 9

Abstract

hSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment. From our screening efforts, we have identified pyrimidine derivatives as hSMG-1 kinase inhibitors. We report structure ...