The Journal of Organic Chemistry

Synthesis and Properties of Isoserine. A Novel Bromhydrination Method

KC LEIBMAN, SK FELLNER

Index: Leibman,K.C.; Fellner,S.K. Journal of Organic Chemistry, 1962 , vol. 27, p. 438 - 440

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Citation Number: 11

Abstract

The bromination of methyl acrylate was carried out in the presence of silver nitrate, which prevented formation of methyl dibromopropionate as a byproduct. Isoserine was synthesized by hydrolysis of the product of amination of methyl bromohydroxypropionate. The copper- catalyzed oxidative deamination of isoserine yielded tartronic acid semialdehyde; under these conditions, hydroxypyruvic acid was produced from serine. Other chemical ...