A very facile SNAr reaction with elimination of methoxide
JW Huffman, MJ Wu, J Lu
Index: Huffman, John W.; Wu, Ming-Jung; Lu, Jianzhong Journal of Organic Chemistry, 1998 , vol. 63, # 13 p. 4510 - 4514
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Citation Number: 15
Abstract
It has been found that 1-alkyl-3-(1-naphthoyl) indoles are potent agonists for the cannabinoid brain receptor and the 1-propyl-2-methyl analogue shows selectivity for the peripheral (spleen) cannabinoid receptor. 1, 2 In the course of preparing a series of 3-(4- methoxy-1-naphthoyl)-indole derivatives designed to be selective agonists for the peripheral receptor, the reaction of 3-(4-methoxy-1-naphthoyl) indole (1) with a series of primary alkyl ...
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