Copper-catalyzed synthesis of five-membered heterocycles via double C–N bond formation: an efficient synthesis of pyrroles, dihydropyrroles, and carbazoles

E Li, X Xu, H Li, H Zhang, X Xu, X Yuan, Y Li

Index: Li, Ende; Xu, Xiaobing; Li, Hongfeng; Zhang, Huimin; Xu, Xiaolei; Yuan, Xiyuan; Li, Yanzhong Tetrahedron, 2009 , vol. 65, # 44 p. 8961 - 8968

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Citation Number: 30

Abstract

An efficient copper-catalyzed double C–N bond forming reaction using diiodides and nitrogen-centered nucleophiles including amides and carbamates is reported. The reactions proceed to afford di-or tri-substituted N-acylpyrroles, dihydropyrroles, and carbazoles in good to excellent yields when different diiodides such as 1, 4-diiodo-1, 3-butadienes, 1, 4- dihalobut-1-enes, and 2, 2′-diiodobiphenyls were employed, respectively. It is crucial to ...