Synthesis of 2, 6, 7-trioxa-4-phosphabicyclo [2.2. 2] octane systems

J Rathke, JW Guyer, JG Verkade

Index: Rathke,J.W. et al. Journal of Organic Chemistry, 1970 , vol. 35, # 7 p. 2310 - 2313

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Citation Number: 13

Abstract

The formation of P (CH20) aP from P (CH20H) a and P (0Me) a is shown to be highly dependent on the manner in which the triol is prepared. Neutralization of [P (CH20H) a] C1 with NaOH produces 1 mol of HzO which is difficult to remove and leads to extensive hydrolysis of the P (OMe) 3 when transesterification is attempted. Treating the salt with an equimolar quantity of NaOMe, although eliminating the hydrolysis problem, results in ...