Six-Membered, Chiral NHCs Derived from Camphor: Structure–Reactivity Relationship in Asymmetric Oxindole Synthesis

MJ Spallek, D Riedel, F Rominger, ASK Hashmi…

Index: Spallek, Markus J.; Riedel, Dominic; Rominger, Frank; Hashmi, A. Stephen K.; Trapp, Oliver Organometallics, 2012 , vol. 31, # 3 p. 1127 - 1132

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Citation Number: 19

Abstract

A series of three chiral, expanded six-membered NHC–palladium (II) complexes was prepared with successively increased sterical demand, while retaining natural d-(+)- camphor as a chiral motif. The catalysts showed different reaction profiles in the asymmetric, intramolecular α-arylation of amides. The molecular structure of two N-heterocyclic and one nitrogen acyclic carbene palladium isonitrile complex was unequivocally determined by X- ...