The Journal of Organic Chemistry

Enzyme-catalyzed hydrolyses of E/Z-diastereotopic and E/Z-diastereomeric esters. Effect on selectivity by reaction media

T Schirmeister, HH Otto

Index: Schirmeister, Tanja; Otto, Hans-Hartwig Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4819 - 4822

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Citation Number: 22

Abstract

Results The diester and ester substrates were prepared by known methods. la-lg (Figure 1) were synthesized by Knoevenagel reaction of the corresponding benzaldehydes* or ketones, & respectively, with diethyl or dimethyl malonate. Diesters 1 h-li are commercially available (Aldrich). Peterson olefination of the C-3-silylated 1, 4-diarylazetidin-2-one with a- keto esters led to the, &lactams 3a-31 (Figure 2). &J)