A novel catalytic one-pot synthesis of carbazoles via consecutive amination and C–H activation

RB Bedford, CSJ Cazin

Index: Bedford, Robin B.; Cazin, Catherine S. J. Chemical Communications, 2002 , # 20 p. 2310 - 2311

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Citation Number: 66

Abstract

We decided to concentrate here on the coupling of anilines as catalytic amination is now a thoroughly studied, well understood process. 2 Brief optimisation studies were performed for the 'double coupling' of N-methyl-2-chloroaniline with 4-bromoanisole. The catalysts studied were complex 1, 3 and the catalysts formed in situ from either dimer 2, 3 [Pd 2 (dba) 3 ] or palladium acetate and the phosphines PR 2 (o-biphenyl) (R = Cy, t Bu) 4 and P t Bu 3 , 5 all of which have ...