Kilogram-scale production of corannulene

AM Butterfield, B Gilomen, JS Siegel

Index: Butterfield, Anna M.; Gilomen, Bruno; Siegel, Jay S. Organic Process Research and Development, 2012 , vol. 16, # 4 p. 664 - 676

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Citation Number: 86

Abstract

An efficient entry process for the synthesis of corannulene has been demonstrated on kilogram scale. Compared to the discovery and gram-scale syntheses, the amounts of solvents and reagents per gram of product were greatly reduced. Priority was given to implement the least toxic agents possible. Improvements in the purification of products obviated the need for column chromatography, alleviating four chromatographic ...