Tetrahedron

Solid-phase synthesis of cyclic polyamines

P Bisegger, N Manov, S Bienz

Index: Bisegger, Pascal; Manov, Nikolay; Bienz, Stefan Tetrahedron, 2008 , vol. 64, # 32 p. 7531 - 7536

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Citation Number: 19

Abstract

A method for the synthesis of cyclic polyamines based on solid-phase chemistry is shown. Linear polyamines are stepwise synthesized on solid support from the center by repetitive alkylations at benzylic N-atoms. Cyclizations at the resins were effected conventionally by direct intramolecular SN2 reactions between sulfonyl-protected terminal amino groups and primary alkyl bromides or by intramolecular Mitsunobu reactions between sulphonamides ...