Preparation of sulfonamides from N-silylamines
RR Naredla, DA Klumpp
Index: Naredla, Rajasekhar Reddy; Klumpp, Douglas A. Tetrahedron Letters, 2013 , vol. 54, # 45 p. 5945 - 5947
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Abstract
Abstract Sulfonamides have been prepared in high yields by the reactions of N-silylamines with sulfonyl chlorides and fluorides. In a competition experiment, the sulfonyl chlorides were found to be far more reactive than sulfonyl fluorides. The chemistry may be used to prepare aliphatic, aromatic, tertiary, secondary, and primary sulfonamides. It may also be done in the absence of solvent and the byproduct trimethylsilyl chloride recovered in good ...
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