Bioorganic & medicinal chemistry

Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN)

C Ma, K Jin, J Cao, L Zhang, X Li, W Xu

Index: Ma, Chunhua; Jin, Kang; Cao, Jiangying; Zhang, Lei; Li, Xiaoguang; Xu, Wenfang Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1621 - 1627

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Citation Number: 5

Abstract

Aminopeptidase N (APN/CD13) over expressed on tumor cells, plays a critical role in tumor invasion, metastasis, and tumor angiogenesis. Here we described the design, synthesis and preliminary activity studies of novel leucine ureido derivatives as aminopeptidase N (APN/CD13) inhibitors. The results showed that compound 8c had the most potent inhibitory activity against APN with the IC50 value to 0.06±0.041 μM, which could be used for further ...