Preparation of chiral 1-phenylethanols and bromides

AR Stein, RD Dawe, JR Sweet

Index: Stein, Allan R.; Dawe, Robert D.; Sweet, James R. Canadian Journal of Chemistry, 1985 , vol. 63, p. 3442 - 3448

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Citation Number: 18

Abstract

A fast, convenient procedure for preparing and resolving moderate to large quantities of chiral secondary alcohols is described. The general procedure involves a one-pot conversion of the ketone (various acetophenones) to the half-ester of a diacid (succinic, phthalic…) and resolution with (+)-and (-)-1-phenylethylamines. Overall yields of the enantiomeric alcohols, the variously substituted 1-phenylethanols, are generally 65-85% ...