Design, synthesis, and evaluation of resveratrol derivatives as Aß 1–42 aggregation inhibitors, antioxidants, and neuroprotective agents

C Lu, Y Guo, J Li, M Yao, Q Liao, Z Xie, X Li

Index: Lu, Chuanjun; Guo, Yueyan; Li, Jianheng; Yao, Meicun; Liao, Qiongfeng; Xie, Zhiyong; Li, Xingshu Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7683 - 7687

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Citation Number: 22

Abstract

A series of novel resveratrol derivatives were designed, synthesised and evaluated as potential therapeutic agents for the treatment of Alzheimer's disease. Among these compounds, compound 7l,(E)-5-(4-(isopropylamino) styryl) benzene-1, 3-diol, exhibited potent ß-amyloid aggregation inhibition activity, which was confirmed by a ThT fluorescence assay (71.65% at 20μM) and transmission electron microscopy (TEM). Compound 7l also ...