Binary antidotes for organophosphate poisoning: Aprophen analogs that are both antimuscarinics and carbamates

…, FN Padilla, BP Doctor, RK Gordon…

Index: Leader; Smejkal; Payne; Padilla; Doctor; Gordon; Chiang Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1522 - 1528

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Citation Number: 28

Abstract

Prophylaxis against organophosphate poisoning can be achieved by pretreatment with physostigmine or pyridostigmine, which are carbamates, and aprophen, which is an anticholinergic agent. Thus, a series of aprophen analogues was synthesized with carbamyl substitutions on the phenyl rings (carbaphens). The rationale behind this design is that such compounds might exhibit most of the therapeutic characteristics of aprophen, as well as ...