Benzyl protection of phenols under neutral conditions: palladium-catalyzed benzylations of phenols
R Kuwano, H Kusano
Index: Kuwano, Ryoichi; Kusano, Hiroki Organic Letters, 2008 , vol. 10, # 10 p. 1979 - 1982
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Citation Number: 52
Abstract
Benzyl protection of phenols under neutral conditions was achieved by using a Pd (η3- C3H5) Cp–DPEphos catalyst. The palladium catalyst efficiently converted aryl benzyl carbonates into benzyl-protected phenols through the decarboxylative etherification. Alternatively, the nucleophilic substitution of benzyl methyl carbonates with phenols proceeded in the presence of the catalyst, yielding aryl benzyl ethers.
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Benzyl protection of phenols under neutral conditions: palladium-catalyzed benzylations of phenols
[Organic Letters, , vol. 10, # 10 p. 1979 - 1982]