Bismuth (III) Halide-Catalyzed Tandem Aldol-Halogenation Reaction: A Convenient Synthesis of. beta.-Halo Ketones and Esters

…, H Gaspard-Iloughmane, J Dubac

Index: Roux, Christophe Le; Gaspard-Iloughmane, Hafida; Dubac, Jacques Journal of Organic Chemistry, 1994 , vol. 59, # 8 p. 2238 - 2240

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Citation Number: 36

Abstract

&Halo carbonyl compounds, including 8-halo acetals, are useful substrates in organic synthesis. 2 However, whereas the methods of synthesis of a-halo carbonyl compounds are numerous, it is apparently more difficult to obtain &halo derivatives which suffer spontaneous dehydrohalogenation if the conditions are too drastic. The main processes used, with some limitations, are olefin acylation3 and addition of hydrogen halides to a,@- ...