Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides

…, G Barta-Szalai, C Kiss, G Tárkányi…

Index: Agai, Bela; Nador, Adrienn; Proszenyak, Agnes; Tarkanyi, Gabor; Faigl, Ferenc Tetrahedron, 2003 , vol. 59, # 40 p. 7897 - 7900

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Citation Number: 35

Abstract

(4-Benzylpiperidine-1-yl)-(6-hydroxy-1 H-indole-2-yl)-methanone (6a) derived from (E)-1-(4- benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was identified as a potent NR2B subunit-selective antagonist of the NMDA receptor. To establish the structure-activity