N-Methyl-5-tert-butyltryptamine: a novel, highly potent 5-HT1D receptor agonist

YC Xu, JM Schaus, C Walker, J Krushinski…

Index: Xu, Yao-Chang; Schaus, John M.; Walker, Clint; Krushinski, Joe; Adham, Nika; Zgombick, John M.; Liang, Sidney X.; Kohlman, Dan T.; Audia, James E. Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 526 - 531

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Citation Number: 19

Abstract

It has been observed that reported 5-HT1D receptor agonists have at least one heteroatom (N, O, or S) on the 5-substituent of the indole. This has led to the hypothesis that a 5- substituent capable of participating in hydrogen bonding is critical for conveying high affinity. This article describes the synthesis and biological evaluation of a new series of 5- alkyltryptamine analogues, which does not have a heteroatom in the 5-substituent group. ...

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N-Methyl-5-tert-butyltryptamine: a novel, highly potent 5-HT1D receptor agonist

Abstract

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