Prostaglandins and congeners. 14. Synthesis and bronchodilator activity of dl-16, 16-trimethyleneprostaglandins

JS Skotnicki, RE Schaub, MJ Weiss…

Index: Skotnicki; Schaub; Weiss Journal of Medicinal Chemistry, 1977 , vol. 20, # 8 p. 1042 - 1047

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Citation Number: 9

Abstract

The prostaglandins, although short-acting, are very potent pharmacological agents with an extraordinarily broad biological profiles2 Recent reports3 indicate that C-15 metabolism apparently is effectively restricted in congeners bearing 16-alkyl substituents, and these