Antibacterial N-[. omega.,. omega.'-bis (alicyclic and aryl)-sec-alkyl] poly (methylenetriamine and-tetramine) hydrochloride salts

N Grier, RA Dybas, RA Strelitz, BE Witzel…

Index: Grier,N. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 1409 - 1414

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Citation Number: 4

Abstract

A series of antibacterial N-[w, o'-(cycloalkyl, bicyclo [2.2. l] heptyl, and alkyl-substituted phenyl)-sec-alkyllpoly-(methy1ene) triamine and-tetramine hydrochloride salts were synthesized in an effort to develop efficient, nonsystemic inhibitors, particularly for Pseudomonas aeruginosa. In the 1, 5, 9-triazanonane group, 3 of 16 compounds were effective at 8-10 rc. g/mL against pseudomonads. Efficiency appeared more dependent ...